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High sensitivity carbon nanotube based electrochemiluminescence sensor array

Identifieur interne : 001A98 ( Main/Repository ); précédent : 001A97; suivant : 001A99

High sensitivity carbon nanotube based electrochemiluminescence sensor array

Auteurs : RBID : Pascal:12-0297759

Descripteurs français

Pascal (Inist)
- Sensibilité, Carbone, Nanotube, Electrochimiluminescence, Réseau capteur, Complexe, Impression à jet d'encre, IgG, Immunoglobuline, Biodétecteur.
Wicri :
- concept : Carbone.

English descriptors

KwdEn :
- Biosensor, Carbon, Complexes, Electrochemiluminescence, IgG, Immunoglobulins, Ink jet printing, Nanotube, Sensitivity, Sensor array.

Abstract

Ink jet printed carbon nanotube forest arrays capable of detecting picomolar concentrations of immunoglobulin G (IgG) using electrochemiluminescence (ECL) are described. Patterned arrays of vertically aligned single walled carbon nanotube (SWCNT) forests were printed on indium tin oxide (ITO) electrodes. Capture anti-IgG antibodies were then coupled through peptide bond formation to acidic functional groups on the vertical nanotubes. IgG immunoassays were performed using silica nano particles (Si NP) functionalized with the ECL luminophore [Ru(bpy)₂PICH₂]²⁺], and IgG labelled G1.5 acid terminated PAMAM dendrimers. PAMAM is poly(amido amine), bpy is 2,2'-bipyridyl and PICH₂ is (2-(4-carboxyphenyl)imidazo[4,5-f][1,10]phenanthroline). The carboxyl terminal of [Ru(bpy)₂PICH₂]²⁺ (fluorescence lifetime ≃ 682 ± 5 ns) dye was covalently coupled to amine groups on the 800 nm diameter silica spheres in order to produce significant ECL enhancement in the presence of sodium oxalate as co-reactant in PBS at pH 7.2). Significantly, this SWCNT-based sensor array shows a wide linear dynamic range for IgG coated spheres (10⁶ to 10¹² spheres) corresponding to IgG concentrations between 20 pM and 300 nM. A detection limit of 1.1±0.1 pM IgG is obtained under optimal conditions.

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Pascal:12-0297759

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">High sensitivity carbon nanotube based electrochemiluminescence sensor array</title>
<author><name sortKey="Venkatanarayanan, Anita" uniqKey="Venkatanarayanan A">Anita Venkatanarayanan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Biomedical Diagnostic Institute, National Center for Sensor Research, School of Chemical Sciences, Dublin City University</s1>
<s2>Dublin 9</s2>
<s3>IRL</s3>
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<country>Irlande (pays)</country>
<wicri:noRegion>Dublin 9</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Crowley, Karl" uniqKey="Crowley K">Karl Crowley</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Biomedical Diagnostic Institute, National Center for Sensor Research, School of Chemical Sciences, Dublin City University</s1>
<s2>Dublin 9</s2>
<s3>IRL</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Irlande (pays)</country>
<wicri:noRegion>Dublin 9</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Lestini, Elena" uniqKey="Lestini E">Elena Lestini</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Chemical Sciences, Dublin City University</s1>
<s2>Dublin 9</s2>
<s3>IRL</s3>
<sZ>3 aut.</sZ>
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<country>Irlande (pays)</country>
<wicri:noRegion>Dublin 9</wicri:noRegion>
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</author>
<author><name sortKey="Keyes, Tia E" uniqKey="Keyes T">Tia E. Keyes</name>
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<author><name sortKey="Rusling, James F" uniqKey="Rusling J">James F. Rusling</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Chemistry, University of Connecticut, 55 North Eagleville Road</s1>
<s2>Storrs, CT06269-3060</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Storrs, CT06269-3060</wicri:noRegion>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Cell Biology, University of Connecticut Health Center</s1>
<s2>Farmington, CT 06032</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Farmington, CT 06032</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Institute of Materials Science, University of Connecticut</s1>
<s2>Storrs, CT 06269</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
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<country>États-Unis</country>
<wicri:noRegion>Storrs, CT 06269</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Chemistry. National University of Ireland</s1>
<s2>Galway</s2>
<s3>IRL</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Irlande (pays)</country>
<wicri:noRegion>Department of Chemistry. National University of Ireland</wicri:noRegion>
</affiliation>
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<author><name sortKey="Forster, Robert J" uniqKey="Forster R">Robert J. Forster</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Biomedical Diagnostic Institute, National Center for Sensor Research, School of Chemical Sciences, Dublin City University</s1>
<s2>Dublin 9</s2>
<s3>IRL</s3>
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<country>Irlande (pays)</country>
<wicri:noRegion>Dublin 9</wicri:noRegion>
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</titleStmt>
<publicationStmt><idno type="inist">12-0297759</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0297759 INIST</idno>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Biosensor</term>
<term>Carbon</term>
<term>Complexes</term>
<term>Electrochemiluminescence</term>
<term>IgG</term>
<term>Immunoglobulins</term>
<term>Ink jet printing</term>
<term>Nanotube</term>
<term>Sensitivity</term>
<term>Sensor array</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Sensibilité</term>
<term>Carbone</term>
<term>Nanotube</term>
<term>Electrochimiluminescence</term>
<term>Réseau capteur</term>
<term>Complexe</term>
<term>Impression à jet d'encre</term>
<term>IgG</term>
<term>Immunoglobuline</term>
<term>Biodétecteur</term>
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<front><div type="abstract" xml:lang="en">Ink jet printed carbon nanotube forest arrays capable of detecting picomolar concentrations of immunoglobulin G (IgG) using electrochemiluminescence (ECL) are described. Patterned arrays of vertically aligned single walled carbon nanotube (SWCNT) forests were printed on indium tin oxide (ITO) electrodes. Capture anti-IgG antibodies were then coupled through peptide bond formation to acidic functional groups on the vertical nanotubes. IgG immunoassays were performed using silica nano particles (Si NP) functionalized with the ECL luminophore [Ru(bpy)<sub>2</sub>
PICH<sub>2</sub>
]<sup>2+</sup>
], and IgG labelled G1.5 acid terminated PAMAM dendrimers. PAMAM is poly(amido amine), bpy is 2,2'-bipyridyl and PICH<sub>2</sub>
 is (2-(4-carboxyphenyl)imidazo[4,5-f][1,10]phenanthroline). The carboxyl terminal of [Ru(bpy)<sub>2</sub>
PICH<sub>2</sub>
]<sup>2+</sup>
 (fluorescence lifetime ≃ 682 ± 5 ns) dye was covalently coupled to amine groups on the 800 nm diameter silica spheres in order to produce significant ECL enhancement in the presence of sodium oxalate as co-reactant in PBS at pH 7.2). Significantly, this SWCNT-based sensor array shows a wide linear dynamic range for IgG coated spheres (10<sup>6</sup>
 to 10<sup>12</sup>
 spheres) corresponding to IgG concentrations between 20 pM and 300 nM. A detection limit of 1.1±0.1 pM IgG is obtained under optimal conditions.</div>
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<sZ>6 aut.</sZ>
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<sZ>3 aut.</sZ>
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<fA14 i1="03"><s1>Department of Chemistry, University of Connecticut, 55 North Eagleville Road</s1>
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<sZ>5 aut.</sZ>
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<fA14 i1="04"><s1>Department of Cell Biology, University of Connecticut Health Center</s1>
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<sZ>5 aut.</sZ>
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<fA14 i1="06"><s1>Department of Chemistry. National University of Ireland</s1>
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<s3>IRL</s3>
<sZ>5 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Ink jet printed carbon nanotube forest arrays capable of detecting picomolar concentrations of immunoglobulin G (IgG) using electrochemiluminescence (ECL) are described. Patterned arrays of vertically aligned single walled carbon nanotube (SWCNT) forests were printed on indium tin oxide (ITO) electrodes. Capture anti-IgG antibodies were then coupled through peptide bond formation to acidic functional groups on the vertical nanotubes. IgG immunoassays were performed using silica nano particles (Si NP) functionalized with the ECL luminophore [Ru(bpy)<sub>2</sub>
PICH<sub>2</sub>
]<sup>2+</sup>
], and IgG labelled G1.5 acid terminated PAMAM dendrimers. PAMAM is poly(amido amine), bpy is 2,2'-bipyridyl and PICH<sub>2</sub>
 is (2-(4-carboxyphenyl)imidazo[4,5-f][1,10]phenanthroline). The carboxyl terminal of [Ru(bpy)<sub>2</sub>
PICH<sub>2</sub>
]<sup>2+</sup>
 (fluorescence lifetime ≃ 682 ± 5 ns) dye was covalently coupled to amine groups on the 800 nm diameter silica spheres in order to produce significant ECL enhancement in the presence of sodium oxalate as co-reactant in PBS at pH 7.2). Significantly, this SWCNT-based sensor array shows a wide linear dynamic range for IgG coated spheres (10<sup>6</sup>
 to 10<sup>12</sup>
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<fC03 i1="01" i2="X" l="FRE"><s0>Sensibilité</s0>
<s5>01</s5>
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<fC03 i1="01" i2="X" l="ENG"><s0>Sensitivity</s0>
<s5>01</s5>
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<s5>02</s5>
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<s5>10</s5>
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<s5>10</s5>
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<s5>11</s5>
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<s5>12</s5>
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<s2>NA</s2>
<s5>19</s5>
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<s2>NA</s2>
<s5>19</s5>
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<s2>NA</s2>
<s5>19</s5>
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<fC03 i1="07" i2="X" l="FRE"><s0>Impression à jet d'encre</s0>
<s5>20</s5>
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<s5>20</s5>
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<s5>20</s5>
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<s5>21</s5>
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<s5>21</s5>
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<s5>35</s5>
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<s5>35</s5>
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</fN21>
<fN44 i1="01"><s1>OTO</s1>
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<fN82><s1>OTO</s1>
</fN82>
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High sensitivity carbon nanotube based electrochemiluminescence sensor array

High sensitivity carbon nanotube based electrochemiluminescence sensor array

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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